Processed Dietary Fiber Partially Hydrolyzed Guar Gum Increases Susceptibility to Colitis and Colon Tumorigenesis in Mice
2024
Processed Dietary Fiber Increases Risk of Colitis and Colon Cancer in Mice
publication
Evidence: moderate
Author Information
Author(s): Tian Sangshan, Goand Umesh K, Paudel Devendra, Le Giang V., Tiwari Amit K., Prabhu K. Sandeep, Singh Vishal
Hypothesis
Does the consumption of partially hydrolyzed guar gum affect gastrointestinal health and the development of colitis and colon cancer?
Conclusion
The study found that partially hydrolyzed guar gum worsens colitis and promotes colon tumor development in mice.
Supporting Evidence
- Phgg feeding exacerbated DSS-induced colitis, leading to body weight loss and increased pro-inflammatory markers.
- Mice fed Phgg showed increased colon tumorigenesis compared to the control group.
- A low-Phgg diet also increased colitis and tumorigenesis, but less severely than the regular Phgg diet.
Takeaway
Eating a certain type of fiber called partially hydrolyzed guar gum can make mice sicker and more likely to get colon cancer.
Methodology
Mice were fed diets with different levels of partially hydrolyzed guar gum and then induced with colitis and colon cancer to assess the effects.
Participant Demographics
Wild-type C57BL/6 mice were used in the study.
Digital Object Identifier (DOI)
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