Neuronal Responses to Anticholinergic Medications
Author Information
Author(s): Pranoto Inez, Schwarze-Taufiq Tiara, Hui Katherine, Zhu Ruowei, Ogg Jordan, Crane Paul, Gray Shelly, Young Jessica
Primary Institution: University of Washington
Hypothesis
Does the use of different classes of anticholinergic medications affect neuronal function and contribute to dementia risk?
Conclusion
Antidepressants and bladder antimuscarinics induce neurotoxicity and alter synaptic gene expression, potentially contributing to dementia risk.
Supporting Evidence
- Antidepressants and bladder antimuscarinics were found to induce neurotoxicity.
- Antihistamines and antispasmodics did not compromise cell viability.
- Exposure to certain anticholinergics increased the secreted A𝛃-42/A𝛃-40 ratio.
Takeaway
Some medications can harm brain cells, which might make people more likely to get dementia.
Methodology
The study used hiPSC-derived neurons from participants in the ACT study and treated them with different anticholinergic medications to assess neuronal responses.
Participant Demographics
Participants were from the Adult Changes in Thought Study, focusing on older adults.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website