Trends in UK Cancer Trials
Author Information
Author(s): Vale C, Stewart L, Tierney J
Primary Institution: MRC Clinical Trials Unit
Hypothesis
We aimed to study trends in the design and conduct of randomised controlled trials (RCTs) in cancer in the UK.
Conclusion
There has been a sustained rise in the total numbers of patients entering UK cancer trials over time with a trend towards larger, multicentre trials.
Supporting Evidence
- Overall, there has been a sustained rise in the total numbers of patients entering UK cancer trials over time.
- Trials have largely been funded by the UK public and charity sectors.
- 83% of the trials were multicentre, indicating a trend towards larger collaborative trials.
Takeaway
This study looked at cancer trials in the UK and found that more people are joining these trials, and they are getting bigger and faster to complete.
Methodology
A descriptive survey of 520 UK RCTs in cancer registered on the UKCCCR NRCT was conducted.
Potential Biases
There may be bias due to unregistered trials, particularly smaller-scale, single-centre trials that may have lower recruitment rates.
Limitations
The UKCCCR NRCT is not fully comprehensive as there is no compulsion for trials to be registered, particularly commercial trials.
Participant Demographics
Trials were conducted in a variety of cancer types, with a significant focus on breast and lung cancer.
Digital Object Identifier (DOI)
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