Patterns of Failure in Gastric Cancer After Surgery and Chemotherapy
Author Information
Author(s): Lim D H, Kim D Y, Kang M K, Kim Y I, Kang W K, Park C K, Kim S, Noh J H, Joh J W, Choi S H, Sohn T S, Heo J S, Park C H, Park J O, Lee J E, Park Y J, Nam H R, Park W, Ahn Y C, Huh S J
Primary Institution: Samsung Medical Center, Sungkyunkwan University School of Medicine
Hypothesis
Does adjuvant radiotherapy reduce locoregional recurrence and improve survival in gastric adenocarcinoma patients after D2 gastrectomy?
Conclusion
Adjuvant chemoradiotherapy may reduce locoregional recurrence rates in gastric adenocarcinoma patients after surgery.
Supporting Evidence
- 291 patients were analyzed for survival and patterns of failure.
- Locoregional recurrence developed in 16% of all treated patients.
- 114 patients (39%) relapsed at 156 sites during the follow-up period.
- The median follow-up period for all patients was 48 months.
- Patients with T3, T4 and/or lymph node metastasis could be candidates for adjuvant therapy.
Takeaway
This study looked at how often gastric cancer comes back after surgery and treatment. It found that some treatments might help keep it from coming back.
Methodology
The study analyzed 291 patients who underwent D2 gastrectomy and received adjuvant chemoradiotherapy, evaluating recurrence patterns and survival rates.
Potential Biases
Potential selection bias as most patients opted for adjuvant treatment.
Limitations
The study was not randomized and may underestimate recurrence patterns.
Participant Demographics
{"male":190,"female":101,"age_60_or_less":210,"age_over_60":81}
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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