Indel PDB: A Database of Structural Insertions and Deletions in Proteins
Author Information
Author(s): Hsing Michael, Cherkasov Artem
Primary Institution: University of British Columbia
Hypothesis
Indel PDB will facilitate the study of structural insertions and deletions in proteins and their roles in biological functions.
Conclusion
Indel PDB provides a comprehensive resource for studying the structural features of indels, which can aid in protein modeling and drug design.
Supporting Evidence
- Indel PDB contains 117,266 non-redundant indel sites extracted from 11,294 indel-containing proteins.
- Indel sites were found to be more exposed to the protein surface than average residues.
- Indel length distribution could be accurately modeled by the Weibull distribution.
- 93.66% of all indel sites overlapped with at least one protein domain.
Takeaway
Indel PDB is a website that helps scientists study tiny changes in proteins that can affect how they work, which is important for understanding diseases and developing new medicines.
Methodology
The database was constructed by analyzing 38,395 PDB structural files, clustering sequences, and identifying indel sites through sequence alignments.
Limitations
The study is limited to the data available in the Protein Data Bank and may not cover all possible indel variations.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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