Aging and Heart Function: How Age Affects Heart Structure and Function
Author Information
Author(s): Janosevic Danielle, Bertman Kathleen, Roth Marguerite, Schapiro William, Passick Michael, Pollack Simcha, Reichek Nathaniel, Cao Jie Jane
Primary Institution: St. Francis Hospital, Roslyn, NY, USA
Hypothesis
Age related remodeling affects systolic and diastolic function and myocardial mechanics.
Conclusion
As people age, their heart shows concentric remodeling and a significant decline in diastolic function, especially in women.
Supporting Evidence
- Diastolic function decreased significantly with aging.
- Women showed greater declines in diastolic function than men.
- LVEDV decreased with aging while LV mass remained unchanged.
Takeaway
As we get older, our hearts change shape and don't work as well, especially when it comes to filling with blood.
Methodology
Participants underwent cardiac MRI and echocardiography to assess heart structure and function.
Potential Biases
Potential selection bias due to the exclusion of individuals with cardiovascular conditions.
Limitations
The study only included normal volunteers without any cardiovascular diseases.
Participant Demographics
Participants were normal volunteers aged 23-85 years, with a mean age of 53.6 years and 52% female.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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