Evaluating Endoscopic Treatments for Sessile Serrated Lesions
Author Information
Author(s): Kagemoto Kaizo, Okamoto Koichi, Okada Yasuyuki, sei Motoko, Fujimoto Shota, Yagi Mai, Mitsuhashi Takeshi, Ueda Hiroyuki, Yoshimoto Takanori, Kashihara Takanori, Kawaguchi Tomoyuki, Kida Yoshifumi, Mitsui Yasuhiro, Kawano Yutaka, Sogabe Masahiro, Miyamoto Hiroshi, Sato Yasushi, Muguruma Naoki, Takayama Tetsuji
Primary Institution: Tokushima University Graduate School
Hypothesis
What is the most suitable endoscopic treatment for sessile serrated lesions (SSL)?
Conclusion
Underwater endoscopic mucosal resection (UEMR) is a suitable treatment option for sessile serrated lesions, while cold snare polypectomy (CSP) results were pathologically insufficient.
Supporting Evidence
- The R0 resection rate was 87% for UEMR, 73% for EMR, and 42% for CSP.
- CSP specimens often contained no submucosal tissue, leading to inadequate resection depth.
- All four SSLD cases received R0 resection by EMR and UEMR.
Takeaway
Doctors are trying to find the best way to remove certain types of growths in the colon. They found that one method works better than others.
Methodology
This was a retrospective study analyzing 92 sessile serrated lesions resected by EMR, CSP, and UEMR, focusing on R0 resection rates and submucosal tissue thickness.
Potential Biases
Selection bias due to the exclusion of fragmented or unstretched lesions.
Limitations
The study was conducted at a single center with a small sample size and retrospective design, which may introduce selection bias.
Participant Demographics
The study included 92 patients with a median age of 65 years, with no significant differences in age, gender, or lesion location among treatment groups.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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