Study Design of PROVHILO: Protective Ventilation During Abdominal Surgery
Author Information
Author(s): Hemmes Sabrine NT, Severgnini Paolo, Jaber Samir, Canet Jaume, Wrigge Hermann, Hiesmayr Michael, Tschernko Edda M, Hollmann Markus W, Binnekade Jan M, Hedenstierna Göran, Putensen Christian, Abreu Marcelo Gama, Pelosi Paolo, Schultz Marcus J
Primary Institution: Academic Medical Center, University of Amsterdam, The Netherlands
Hypothesis
A lung-protective mechanical ventilation strategy with higher levels of PEEP and recruitment maneuvers attenuates post-operative pulmonary complications in patients without lung injury.
Conclusion
The PROVHILO trial aims to determine if a protective ventilation strategy reduces post-operative pulmonary complications compared to conventional ventilation.
Supporting Evidence
- Post-operative pulmonary complications increase morbidity and mortality after surgery.
- Mechanical ventilation can cause or worsen lung injury.
- Using higher levels of PEEP may reduce atelectasis during surgery.
Takeaway
This study is testing if using special breathing techniques during surgery can help patients avoid lung problems after they wake up.
Methodology
A multicenter randomized controlled trial comparing two mechanical ventilation strategies in patients undergoing non-laparoscopic abdominal surgery.
Limitations
Patients with certain pre-existing conditions or those undergoing laparoscopic surgery are excluded from the study.
Participant Demographics
Patients scheduled for non-laparoscopic abdominal surgery at high or intermediate risk for post-operative pulmonary complications.
Digital Object Identifier (DOI)
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