Genetics of Saline and Cocaine Self-Administration in Mice
Author Information
Author(s): Khan Arshad H., Bagley Jared R., LaPierre Nathan, Gonzalez-Figueroa Carlos, Spencer Tadeo C., Choudhury Mudra, Xiao Xinshu, Eskin Eleazar, Jentsch James D., Smith Desmond J.
Primary Institution: Department of Molecular and Medical Pharmacology, Geffen School of Medicine, UCLA
Hypothesis
To identify genes involved in regulating the behavioral and brain transcriptomic response to cocaine and saline.
Conclusion
The study found distinct genetic bases for saline and cocaine self-administration in mice.
Supporting Evidence
- 145 loci were identified for saline self-administration compared to 17 for cocaine.
- Only one locus overlapped between cocaine and saline self-administration.
- Significant heritabilities were found for saline IVSA compared to cocaine.
Takeaway
Scientists studied mice to see how their genes affect their behavior when given cocaine or saline, finding that different genes are involved for each.
Methodology
Genome-wide association studies (GWASs) and transcriptome-wide association studies (TWASs) were performed on mice over 10 days.
Limitations
The physiological relevance of saline IVSA remains unknown.
Participant Demographics
Mice from 84 strains of the hybrid mouse diversity panel.
Statistical Information
P-Value
6.6 × 10−10
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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