Genomic Imprinting of Certain Genes in Cattle
Author Information
Author(s): Zaitoun Ismail, Khatib Hasan
Primary Institution: Department of Dairy Science, University of Wisconsin-Madison
Hypothesis
The study aims to assess the imprinting status and expression patterns of the SLC38A4, NNAT, NAP1L5, and H19 genes in bovine tissues.
Conclusion
The study found that SLC38A4 is not imprinted in cattle, while NAP1L5, NNAT, and H19 show conserved imprinting patterns similar to those in mice.
Supporting Evidence
- SLC38A4 is expressed in all adult tissues examined.
- NNAT shows paternal expression in a wide range of tissues.
- H19 is maternally expressed like its orthologues in other species.
Takeaway
The researchers looked at how certain genes work in cattle and found that one gene is active in all tissues, while others behave differently than in mice.
Methodology
A polymorphism-based approach was used to assess the imprinting status of four bovine genes in a total of 75 tissue types obtained from 12 fetuses and their dams.
Participant Demographics
12 fetuses and their dams
Digital Object Identifier (DOI)
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