Evaluation of Chromosomal Instability in Diabetic Rats Treated with Naringin
2011

Naringin Reduces Chromosomal Instability in Diabetic Rats

Sample size: 30 publication 10 minutes Evidence: moderate

Author Information

Author(s): A. Bakheet Saleh, M. Attia Sabry

Primary Institution: King Saud University

Hypothesis

Can naringin reduce chromosomal instability in diabetic rats?

Conclusion

Naringin has a protective effect against diabetes-induced chromosomal instability in rat somatic and germinal cells.

Supporting Evidence

  • Naringin treatment significantly reduced DNA strand breaks in diabetic rats.
  • Naringin improved sperm count and reduced abnormalities in diabetic rats.
  • Naringin decreased oxidative stress markers in sperm cells of diabetic rats.

Takeaway

Naringin, a compound found in grapefruit, helps protect diabetic rats from DNA damage.

Methodology

The study used various assays to assess DNA damage and chromosomal aberrations in diabetic rats treated with naringin.

Limitations

The study was conducted on rats, and results may not directly translate to humans.

Participant Demographics

Adult Wistar albino male rats, weighing 250–300 g.

Statistical Information

P-Value

p<0.01

Statistical Significance

p<0.01

Digital Object Identifier (DOI)

10.1155/2011/365292

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