A retrospective study of breast carcinoma: causes of death and pattern of metastases
1989

Study of Causes of Death in Breast Cancer Patients

Sample size: 85 publication Evidence: moderate

Author Information

Author(s): D.M. Parham, A.J. Robertson

Primary Institution: University of Dundee

Hypothesis

What are the causes of death and patterns of metastases in breast carcinoma patients?

Conclusion

Only 29% of breast carcinoma patients died directly from the disease, highlighting discrepancies in clinical assessments.

Supporting Evidence

  • Only 25 out of 85 patients died directly from breast carcinoma.
  • Clinical assessments were correct in identifying breast cancer as the cause of death in only 75% of suspected cases.
  • The median survival for breast carcinoma deaths was significantly shorter than for non-breast cancer deaths.

Takeaway

This study looked at women who died from breast cancer and found that many didn't actually die from the cancer itself.

Methodology

Reviewed autopsy reports and clinical summaries for female patients with breast carcinoma from March 1973 to September 1986.

Potential Biases

There may be a tendency to over-diagnose breast cancer as a cause of death in previously treated patients.

Limitations

The study relied on retrospective data and may not capture all relevant cases or causes of death.

Participant Demographics

Female patients with a history of breast carcinoma, mean age 60 years.

Statistical Information

P-Value

0.008

Statistical Significance

p=0.008

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