Proteomic Analysis of Anti-Tumor Effects of 11-Dehydrosinulariolide on CAL-27 Cells
2011
Effects of 11-Dehydrosinulariolide on CAL-27 Cancer Cells
Sample size: 27
publication
Evidence: moderate
Author Information
Author(s): Liu Chih-I, Chen Cheng-Chi, Chen Jiing-Chuan, Su Jui-Hsin, Huang Han Hsiang, Chen Jeff Yi-Fu, Wu Yu-Jen
Primary Institution: Meiho University
Hypothesis
The study investigates the anti-tumor effects of 11-dehydrosinulariolide on CAL-27 cells.
Conclusion
11-Dehydrosinulariolide significantly reduces the viability of CAL-27 cells and induces apoptosis.
Supporting Evidence
- Increasing concentrations of 11-dehydrosinulariolide decreased CAL-27 cell viability.
- At 1.5 μg/mL, CAL-27 cell viability was reduced to 70% of the control.
- Treatment induced both early and late apoptosis in CAL-27 cells.
- A total of 28 differential proteins were identified in treated CAL-27 cells.
Takeaway
This study shows that a substance from soft coral can make cancer cells die and stop them from growing.
Methodology
The study used MTT assay, flow cytometry, and comparative proteomic analysis to assess the effects of 11-dehydrosinulariolide on CAL-27 cells.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website