Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis
1999
How Low Oxygen Levels Help Melanoma Spread
Sample size: 2
publication
Evidence: moderate
Author Information
Author(s): Rofstad E K, Danielsen T
Primary Institution: Institute for Cancer Research, Oslo, The Norwegian Radium Hospital
Hypothesis
Can hypoxia-induced VEGF up-regulation increase the metastatic efficiency of human melanoma cells?
Conclusion
Hypoxia can enhance the metastatic potential of low VEGF-expressing melanoma cells by increasing VEGF secretion.
Supporting Evidence
- Both melanoma cell lines increased VEGF secretion under hypoxic conditions.
- The D-12 cell line showed increased metastatic efficiency after hypoxia exposure.
- The A-07 cell line did not show changes in metastatic efficiency after hypoxia.
Takeaway
When melanoma cells are in low oxygen, they can produce a substance that helps them spread more easily. This is especially true for certain types of melanoma cells.
Methodology
Melanoma cell lines were exposed to hypoxia, and their metastatic efficiency, transplantability, and angiogenic potential were assessed in mice.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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