Increasing Antibody Uptake in Tumors
Author Information
Author(s): T.W. Hennigan, R.H. J. Begent, T.G. Allen-Mersh
Primary Institution: Charing Cross and Westminster Medical School
Hypothesis
Can agents that increase capillary permeability enhance the uptake of antibody in tumors?
Conclusion
Increasing tumor capillary permeability can significantly improve the uptake of antibody-isotope conjugates in tumors.
Supporting Evidence
- Regionally administered anti-CEA antibody resulted in a significantly greater tumor to normal tissue ratio compared to systemic administration.
- The addition of vasoactive drugs produced an approximately 3-fold increase in tumor uptake.
- Histamine significantly increased the mean tumor to liver ratio of non-specific antibody uptake.
Takeaway
This study found that using certain drugs can help more medicine get into tumors, which might help treat cancer better.
Methodology
A xenograft model of colorectal carcinoma was developed, and antibody uptake was measured after administering agents that increase capillary permeability.
Limitations
The study does not prove that the increase in antibody uptake was solely due to changes in capillary permeability.
Participant Demographics
Genetically immunocompromised rats were used in the study.
Statistical Information
P-Value
P < 0.001
Statistical Significance
p<0.001
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