HOXD13 and Its Role in Oral Squamous Cell Carcinoma
Author Information
Author(s): Ma Xingyue, Zhang Xiao, Li Haiyang, Mei Shuang, Wang Bowen, Guan Shuai, Wang Yitong, Li Yuantao, Li Siyi, Li Xiangjun
Primary Institution: Hebei Medical University
Hypothesis
Elevated levels of HOXD13 are present in OSCC tissues and correlate with poor prognosis.
Conclusion
HOXD13 is significantly upregulated in OSCC, and its inhibition reduces OSCC cell proliferation and migration.
Supporting Evidence
- HOXD13 was notably upregulated in OSCC tissues and cell lines, showing high diagnostic potential with an AUC of 0.9.
- Stable knockdown of HOXD13 in OSCC cell lines resulted in a marked reduction in cell proliferation and migration.
- Proteomic analysis post-HOXD13 knockdown highlighted alterations in fatty acid degradation pathways.
Takeaway
This study found that a gene called HOXD13 is higher in oral cancer cells, and when it's turned down, the cancer cells grow and move less.
Methodology
The study analyzed OSCC samples from TCGA and GEO databases, identified differentially expressed genes, and assessed the impact of HOXD13 knockdown on cell proliferation and migration using various assays.
Limitations
The use of the BC algorithm for identifying hub genes may differ from other methods, and the selection criteria for gene screening lack universal guidelines.
Participant Demographics
Patients diagnosed with OSCC at the Stomatological Hospital of Hebei Medical University and Cangzhou Central Hospital.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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