NT-proBNP and Atherosclerosis in Diabetic Patients
Author Information
Author(s): Reinhard Henrik, Wiinberg Niels, Hansen Peter R, Kjær Andreas, Petersen Claus L, Winther Kaj, Parving Hans-Henrik, Rossing Peter, Jacobsen Peter K
Primary Institution: Steno Diabetes Center, Gentofte, Denmark
Hypothesis
Is NT-proBNP an independent predictor of atherosclerosis in asymptomatic type 2 diabetic patients with microalbuminuria?
Conclusion
Half of asymptomatic patients with type 2 diabetes and microalbuminuria had significant atherosclerosis in at least one vascular territory despite intensive treatment.
Supporting Evidence
- 49% of patients had atherosclerosis in one territory.
- 35% had coronary atherosclerosis.
- Low RHI was an independent predictor of coronary atherosclerosis.
- Patients with elevated NT-proBNP did not have more overall atherosclerosis.
Takeaway
This study found that many people with diabetes have hardening of the arteries, even if they feel fine and are getting good treatment.
Methodology
Cross-sectional study measuring NT-proBNP and assessing atherosclerosis in coronary, carotid, and peripheral arteries.
Potential Biases
Potential selection bias due to the specific patient group studied.
Limitations
The study was limited to a selected cohort of patients and may not represent the general population.
Participant Demographics
Asymptomatic type 2 diabetic patients with microalbuminuria, average age 59 years.
Statistical Information
P-Value
0.003
Confidence Interval
1.15-5.88
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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