α-Tocopheryl succinate sensitises a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-κB activation
2003
Vitamin E Compound Boosts Cancer Cell Death
publication
Evidence: moderate
Author Information
Author(s): Dalen H, Neuzil J
Primary Institution: The Gade Institute, University of Bergen, Norway
Hypothesis
Can α-tocopheryl succinate enhance the sensitivity of Jurkat T lymphoma cells to TRAIL-induced apoptosis by inhibiting NF-κB activation?
Conclusion
α-Tocopheryl succinate enhances TRAIL-induced apoptosis in Jurkat T lymphoma cells by inhibiting NF-κB activation.
Supporting Evidence
- α-Tocopheryl succinate is a potent inducer of apoptosis in various cells.
- Normal cells appear to overexpress decoy receptors that inhibit TRAIL-induced apoptosis.
- TRAIL can selectively induce apoptosis in cancer cells while sparing normal cells.
Takeaway
A special form of vitamin E helps cancer cells die when combined with a specific immune signal, making it a potential treatment for cancer.
Methodology
Jurkat T lymphoma cells were treated with α-tocopheryl succinate and TRAIL, and apoptosis was assessed using annexin V-binding and caspase-3 activation methods.
Digital Object Identifier (DOI)
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