Role of TGF-β signaling in inherited and acquired myopathies
Author Information
Author(s): Tyesha N Burks, Ronald D Cohn
Primary Institution: Johns Hopkins University School of Medicine
Hypothesis
Dysregulation of TGF-β signaling contributes to various inherited and acquired myopathies.
Conclusion
Increased activity of the TGF-β superfamily plays an important role in the pathogenesis of both inherited and acquired forms of neuromuscular disorders.
Supporting Evidence
- TGF-β1 is linked to muscle growth and regeneration but can also cause muscle atrophy when elevated.
- Inhibition of TGF-β signaling has shown potential in improving muscle regeneration in various myopathic conditions.
- Chronic exposure to TGF-β1 can lead to fibrosis and impaired muscle healing.
Takeaway
TGF-β is a signaling molecule that helps muscles grow and heal, but too much of it can cause muscle problems. Researchers are looking for ways to block TGF-β to help treat muscle diseases.
Methodology
This review discusses the role of TGF-β signaling in muscle health and disease, focusing on its effects in various myopathies and potential therapeutic interventions.
Limitations
The review primarily focuses on TGF-β signaling and may not cover all factors involved in myopathies.
Digital Object Identifier (DOI)
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