Tumour Size and Liposome Uptake in Cancer
Author Information
Author(s): Harrington K J, Rowlinson-Busza G, Syrigos K N, Abra R M, Uster P S, Peters A M, Stewart J S W
Primary Institution: ICRF Oncology Unit, Imperial College of Science, Technology and Medicine, Hammersmith Hospital
Hypothesis
How does tumour size affect the uptake of pegylated liposomes in a human tumour model?
Conclusion
Larger tumours have lower uptake of pegylated liposomes, indicating poor vascularization.
Supporting Evidence
- The mean tumour uptake of 111In-labelled pegylated liposomes at 24 hours was 7.2 ± 6.6% ID/g.
- Liposome uptake decreased as tumour size increased: 15.1 ± 10.8% ID/g for tumours < 0.1 g, 5.9 ± 2.2% ID/g for 0.1–1.0 g, and 3.0 ± 1.3% ID/g for > 1.0 g.
- An inverse correlation between tumour weight and liposome uptake was observed.
- For tumours with central necrosis, the uptake ratio in the tumour rim relative to the necrotic core was 11.2 ± 6.4.
- There was also an inverse correlation between tumour weight and vascular volume.
Takeaway
Bigger tumours don't absorb as much medicine in liposomes, which could make treatment harder.
Methodology
The study examined the relationship between tumour size and liposome uptake in a human head and neck cancer xenograft model using nude mice.
Participant Demographics
Nude mice with human head and neck cancer xenografts.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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