Lewis Phenotype in Pregnant Women with Preterm Labor
Author Information
Author(s): William F. O'Brien, German F. Leparc, Jodi Holbrook
Primary Institution: University of South Florida College of Medicine
Hypothesis
Is there an association between Lewis phenotype status in pregnant women and preterm labor or premature rupture of membranes?
Conclusion
The study found no association between Lewis phenotype and the occurrence of preterm labor or premature rupture of membranes.
Supporting Evidence
- Pregnancy was associated with a higher frequency of the a-b- phenotype.
- There was no significant difference in Lewis phenotype between the control and PTL or PROM groups.
- The study confirmed altered distribution of erythrocyte Lewis phenotype expression during pregnancy.
Takeaway
The study looked at whether a specific blood type trait in pregnant women affects their risk of early labor or water breaking, and it found that it doesn't.
Methodology
The study determined the Lewis phenotype in 113 pregnant women with preterm labor or premature rupture of membranes and 121 control subjects.
Limitations
The study may not have had enough participants to detect a small effect of Lewis antigen status on preterm labor or premature rupture of membranes.
Participant Demographics
Participants included pregnant women with singleton pregnancies, with a mix of races.
Statistical Information
Statistical Significance
p<0.05
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