Selective Breeding Changes Mouse Digit Ratio
Author Information
Author(s): Yan Reginia H. Y., Malisch Jessica L., Hannon Robert M., Hurd Peter L., Garland Theodore Jr
Primary Institution: University of Alberta, University of California Riverside
Hypothesis
If digit ratio reflects the organizational effects of testosterone, then we would find a consistent sex difference in the mice.
Conclusion
Selective breeding for high voluntary exercise in mice increased the 2D:4D digit ratio, suggesting a 'feminization' effect contrary to human studies.
Supporting Evidence
- Mice from the selected lines showed higher 2D:4D ratios than control lines.
- Females had higher 2D:4D ratios than males in the selected lines.
- The study suggests that digit ratio may reflect glucocorticoid effects rather than just testosterone.
Takeaway
The study found that breeding mice for exercise made their finger ratios more like those of females, which is different from what we see in humans.
Methodology
Mice were selectively bred for high rates of voluntary exercise, and their digit ratios were measured and compared to control lines.
Limitations
The study may not directly correlate mouse behavior with human behavior due to differences in physical fitness measures.
Participant Demographics
Mice from selected (High Runner) and control lines were used in the study.
Statistical Information
P-Value
p=0.0115 for sex difference in selected lines
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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