Disturbed α-Cell Function in Mice with β-Cell Specific Overexpression of Human Islet Amyloid Polypeptide
2008
Effects of Human Islet Amyloid Polypeptide on Glucagon and Insulin in Mice
Sample size: 11
publication
Evidence: moderate
Author Information
Author(s): Bo Ahrén, Maria Sörhede Winzell
Primary Institution: Lund University
Hypothesis
Do mice with β-cell specific overexpression of human IAPP have disturbed glucagon secretion?
Conclusion
Mice with β-cell specific overexpression of human IAPP have higher baseline glucagon levels and an impaired glucagon response to oral protein.
Supporting Evidence
- Transgenic mice had higher baseline glucagon levels than wildtype mice.
- The glucagon response to protein was impaired in transgenic mice.
- Baseline insulin levels did not differ significantly between the groups.
Takeaway
This study found that special mice with a certain protein have too much glucagon and don't respond well to protein like normal mice do.
Methodology
The study involved transgenic and wildtype mice receiving an oral protein load, followed by blood sample analysis for glucagon and insulin levels.
Participant Demographics
Female transgenic and wildtype mice
Statistical Information
P-Value
P = .015, P = .027, P = .018
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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