Immunohistochemical expression of EGP40, a tumor marker, in different grades of oral squamous cell carcinoma
2011
EGP40 Expression in Oral Squamous Cell Carcinoma
Sample size: 30
publication
Evidence: moderate
Author Information
Author(s): Vineeta Gupta, Nirmala N
Primary Institution: College of Dental Surgery, Manipal, India
Hypothesis
The study aims to investigate the distribution and pattern of staining of EGP40 in different grades of oral squamous cell carcinoma.
Conclusion
EGP40 expression increases as the grade of oral squamous cell carcinoma worsens from well to poorly differentiated.
Supporting Evidence
- EGP40 expression showed an inverse relationship to differentiation in oral squamous cell carcinoma.
- Expression of EGP40 became more pronounced as the grade of carcinoma worsened.
- Statistical significance was observed between different grades of OSCC in relation to cytoplasmic and membranous staining.
Takeaway
The study found that a protein called EGP40 is more visible in more serious cases of a type of mouth cancer.
Methodology
The study analyzed 30 biopsy reports of oral squamous cell carcinoma using immunoperoxidase staining.
Limitations
Further studies are required to understand the dualistic role of EGP40 in tumor invasion and metastasis.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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