BCL2A1 Expression Increases with Acute Chorioamnionitis in Preterm Birth
Author Information
Author(s): Park Chan-Wook, Lee Eun-Mi, Shin Seung-Han, Lee Chul, Won Jae-Kyung
Primary Institution: Seoul National University College of Medicine
Hypothesis
Does the intensity of BCL2A1 expression increase according to the stage progression of acute histologic chorioamnionitis in extra-placental membranes among spontaneous preterm birth cases?
Conclusion
The intensity of BCL2A1 expression increases according to the stage progression of acute chorioamnionitis in extra-placental membranes and correlates with the elevation of amniotic fluid white blood cell counts.
Supporting Evidence
- The percentage of BCL2A1-positive cells significantly increases with the stage progression of acute HCA.
- BCL2A1 expression correlates positively with amniotic fluid WBC count.
- BCL2A1 expression decreases with increasing gestational age at delivery.
Takeaway
This study found that a protein called BCL2A1 gets more active as a condition called chorioamnionitis gets worse in pregnant women who give birth early.
Methodology
The study used digital image analysis with QuPath to measure BCL2A1-positive cells in extra-placental membranes from 121 singleton preterm births.
Limitations
The study did not investigate BCL2A1 gene-related markers in maternal plasma for predicting acute chorioamnionitis.
Participant Demographics
All participants were singleton pregnancies with gestational ages at delivery less than 34 weeks due to preterm labor or preterm PROM.
Statistical Information
P-Value
p<0.000001
Statistical Significance
p<0.000001
Digital Object Identifier (DOI)
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