Vitamin B1, B2, and B6 Intakes and Risk of Gastric Cancer
Author Information
Author(s): Le Ngoan Tran, Pham Yen T.-H., Dang Huy Thanh, Le Linh Thuy, Huynh Nhi Y.-N., Cullen Jennifer, Luu Hung N., Nexø Ebba
Primary Institution: Institute of Research and Development, Duy Tan University, Da Nang, Vietnam
Hypothesis
What is the association between dietary intakes of vitamins B1, B2, and B6 and the risk of gastric cancer?
Conclusion
Dietary vitamins B1 and B6 were associated with a reduced risk of gastric cancer in the Vietnamese population.
Supporting Evidence
- Overall, dietary vitamins B1 and B6 were associated with a reduced risk of gastric cancer.
- Compared with the lowest quintile, higher intakes of vitamin B1 and B6 significantly lowered gastric cancer risk.
- The inverse association was consistent across different sex and BMI categories.
- No association was found between dietary vitamin B2 and gastric cancer risk.
Takeaway
Eating more vitamins B1 and B6 might help lower the chances of getting stomach cancer.
Methodology
A hospital-based case-control study with dietary assessment using a validated food frequency questionnaire and unconditional logistic regression for analysis.
Potential Biases
Potential selection bias from using hospital controls and recall bias in dietary assessments.
Limitations
Selection bias may exist due to the hospital-based design, and recall bias could affect dietary reporting.
Participant Demographics
Participants included 1182 gastric cancer patients and 2995 controls, with varying demographics including age, sex, and education level.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 0.78–0.89 for vitamin B1; 95% CI: 0.81–0.94 for vitamin B6
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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