Safety of Stored Blood for Neonatal Transfusions
Author Information
Author(s): Mukherjee Somnath, Marwaha Neelam, Prasad Rajendra, Sharma Ratti Ram, Thakral Beenu
Primary Institution: Postgraduate Institute of Medical Education & Research, Chandigarh, India
Hypothesis
This study evaluates the biochemical changes in red blood cell preparations during storage to assess their safety for neonatal transfusions beyond one week.
Conclusion
The study found that biochemical changes in stored red blood cell preparations remain within acceptable safety limits for up to 21 days.
Supporting Evidence
- CPDA-1 RBCs showed the highest increase in potassium levels during storage.
- SAGM RBC maintained a higher pH compared to CPDA-1 RBC from day 3 to 21.
- Glucose levels decreased significantly in all RBC preparations over time.
Takeaway
Doctors want to use fresh blood for babies, but this study shows that stored blood can still be safe to use for up to three weeks.
Methodology
Twenty-five units each of whole blood, CPDA-1 RBC, and SAGM RBC were assessed for biochemical parameters over 21 days.
Limitations
The study did not assess the in vivo effects of transfusing stored blood in neonates.
Participant Demographics
Neonates requiring transfusions.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.05
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