Human papillomavirus infection as a risk factor for anal and perianal skin cancer in a prospective study

2002

HPV Infection and Anal Cancer Risk

Sample size: 28 publication Evidence: high

Author Information

Author(s): Bjørge T, Engeland A, Luostarinen T, Mork J, Gislefoss R E, Jellum E, Koskela P, Lehtinen M, Pukkala E, Thoresen SØ, Dillner J

Primary Institution: The Norwegian Radium Hospital

Does human papillomavirus infection increase the risk of anal and perianal skin cancer?

The study found that infection with HPV 16 and 18 significantly increases the risk of developing anal and perianal skin cancer.

HPV 16 and 18 were found to significantly increase the risk of anal and perianal skin cancer.
28 cases of anal and perianal skin cancer were identified in the study.
Seropositivity for HPV 16 was observed in 50% of the cancer cases.

If you have a virus called HPV, it can make you more likely to get certain types of cancer around your bottom.

A case-cohort study was conducted using serum samples from two large Nordic serum banks, analyzing the presence of IgG antibodies to HPV types.

There may be risks of bias due to the retrospective nature of some data collection.

The study may have limitations related to the matching criteria and the potential for misclassification.

The study included both men and women, with a median age of 57 years for Norwegian cases and 39 years for Finnish cases.

OR=3.0 for HPV 16; OR=4.4 for HPV 18

95%CI=1.1–8.2 for HPV 16; 95%CI=1.1–17 for HPV 18

p<0.05

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