Sub-Telomeric core X and Y' Elements in S.cerevisiae Suppress Extreme Variations in Gene Silencing
2011
Core X and Y' Elements in Yeast Suppress Variations in Gene Silencing
publication
Evidence: moderate
Author Information
Author(s): Patricia Power, Daniel Jeffery, Muhammad Attiq, Arjun Chatterji, Krassimir Yankulov
Primary Institution: Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada
Hypothesis
Do core X and Y' elements in subtelomeric regions affect gene silencing variations in yeast?
Conclusion
Core X and Y' elements help stabilize gene silencing in yeast, reducing extreme variations caused by mutations.
Supporting Evidence
- Core X and Y' elements dampen extreme variations in telomere position effect (TPE).
- Deletion of histone-acetyltransferase genes reduces silencing activity.
- Core X and Y' maintain epigenetic plasticity of subtelomeric gene expression.
Takeaway
This study shows that certain parts of yeast chromosomes help keep gene activity stable, even when other parts are changed.
Methodology
The study involved creating different telomeric constructs and analyzing their effects on gene silencing in various yeast strains.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website