Genetic Factors and Ischemic Stroke Risk in Singaporean Chinese
Author Information
Author(s): Low Hui-Qi, Chen Christopher P. L. H., Kasiman Katherine, Thalamuthu Anbupalam, Ng Seok-Shin, Foo Jia-Nee, Chang Hui-Meng, Wong Meng-Cheong, Tai E-Shyong, Liu Jianjun
Primary Institution: Human Genetics, Genome Institute of Singapore, Singapore
Hypothesis
Are there genetic variants in homocysteine metabolism genes that increase the risk of ischemic stroke in Singaporean Chinese individuals?
Conclusion
The study suggests that while no single genetic variant was significantly associated with ischemic stroke, the cumulative effect of several small to moderate risk variants may increase the risk.
Supporting Evidence
- The study analyzed 25 genes involved in homocysteine metabolism.
- Three SNPs showed suggestive association with ischemic stroke risk.
- The joint effect of risk alleles was significantly associated with increased stroke risk.
Takeaway
The study looked at genes that might affect stroke risk and found that having more of certain genetic variants could increase the chance of having a stroke.
Methodology
The study involved two stages: an initial analysis of 360 stroke patients and 354 controls, followed by a replication study with 420 matched case-control pairs, focusing on SNP and haplotype-based association analyses.
Potential Biases
Potential bias due to the age difference between cases and controls in the replication study.
Limitations
The replication study did not find significant associations, possibly due to smaller sample sizes and younger controls.
Participant Demographics
Participants were Singaporean Chinese, aged 40 to 85, with a mix of stroke patients and healthy controls.
Statistical Information
P-Value
1.2×10−6
Confidence Interval
95% CI, 30-90%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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