DRAMP 4.0: An Open-Access Data Repository for Antimicrobial Peptides
Author Information
Author(s): Ma Tianyue, Liu Yanchao, Yu Bingxin, Sun Xin, Yao Huiyuan, Hao Chen, Li Jianhui, Nawaz Maryam, Jiang Xun Mudi Meng, Lao Xingzhen, Zheng Heng
Primary Institution: China Pharmaceutical University
Hypothesis
The update of the Data Repository of Antimicrobial Peptides (DRAMP) aims to enhance the clinical translation of antimicrobial peptides by adding new stability annotations and updating hemolytic/cytotoxic information.
Conclusion
DRAMP 4.0 significantly expands the database with over 30,000 entries and includes new stability data to aid in the design of effective antimicrobial peptides.
Supporting Evidence
- DRAMP 4.0 contains 30,260 entries, including 8,001 newly added.
- 110 antimicrobial peptides with experimentally determined stability information have been added.
- 2891 entries possess experimentally determined hemolytic activity information.
Takeaway
This study created a big online library of antimicrobial peptides to help scientists find new medicines to fight superbugs.
Methodology
Data was collected from literature and patents using specific keywords, and entries were manually reviewed and annotated for stability and cytotoxicity.
Limitations
The database may not include all relevant antimicrobial peptides due to varying inclusion criteria across different databases.
Digital Object Identifier (DOI)
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