Suppressed tumorigenicity of human endometrial cancer cells by the restored expression of the DCC gene
2000
DCC Gene Suppresses Endometrial Cancer Growth
publication
Evidence: moderate
Author Information
Author(s): Kato H, Zhou Y, Asanoma K, Kondo H, Yoshikawa Y, Watanabe K, Matsuda T, Wake N, Barrett J C
Primary Institution: Medical Institute of Bioregulation, Kyushu University
Hypothesis
The DCC gene acts as a tumor suppressor in endometrial cancer cells.
Conclusion
Restoring the DCC gene in endometrial cancer cells significantly reduces tumor formation.
Supporting Evidence
- The DCC gene was completely deleted in the cancer cells before restoration.
- Restored DCC expression suppressed tumor formation in mice.
- Ishikawa clones with DCC expression showed reduced growth and an apoptotic phenotype.
Takeaway
Scientists found that a gene called DCC can help stop cancer cells from growing in the uterus.
Methodology
The DCC gene was reintroduced into tumorigenic endometrial cancer cells to observe its effects on growth and tumor formation.
Digital Object Identifier (DOI)
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