6-Amino-1,3-dimethyl-5-[(E)-2-(methylsulfanyl)benzylideneamino]pyrimidine-2,4(1H,3H)-dione
2011
Crystal Structure of a Schiff Base Compound
publication
Evidence: moderate
Author Information
Author(s): Booysen Irvin, Muhammed Ismail, Soares Anna, Gerber Thomas, Hosten Eric, Betz Richard
Primary Institution: University of Kwazulu-Natal
Hypothesis
The study aims to determine the crystal structure of a Schiff base derivative of 2-(methylsulfanyl)benzaldehyde.
Conclusion
The crystal structure reveals the compound's planar configuration and the presence of hydrogen bonds linking molecules.
Supporting Evidence
- The compound is a Schiff base featuring an ortho-(thiomethyl)phenyl moiety.
- The configuration about the C=N double bond is E.
- An intramolecular N—H⋯S hydrogen bond is observed.
- N—H⋯O and C—H⋯O hydrogen bonds link molecules into layers.
Takeaway
The researchers looked at a special type of chemical compound and found out how its atoms are arranged in a solid form.
Methodology
The compound was synthesized by refluxing equimolar amounts of ortho-(thiomethyl)-benzaldehyde and 5,6-diamino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione in anhydrous methanol.
Digital Object Identifier (DOI)
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