Gene Conversion in Entamoeba
Author Information
Author(s): Gareth D. Weedall, James Paterson, Steve Hall, Neil Lohia
Primary Institution: Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
Hypothesis
The difference in virulence between E. histolytica and E. dispar may be mediated by adaptive differences in the Gal/GalNAc lectin complex.
Conclusion
Gene conversion has occurred among members of the Gal/GalNAc lectin gene families in Entamoeba, suggesting a mechanism for immune evasion.
Supporting Evidence
- Gene conversion generates diversity among genes in pathogenic protozoa.
- High dS values in lectin genes suggest gene conversion rather than positive selection.
- Phylogenetic analysis supports the occurrence of gene conversion among igl genes.
Takeaway
The study found that a process called gene conversion helps the Entamoeba parasite change its genes to avoid being detected by the immune system.
Methodology
The study analyzed genes encoding the Gal/GalNAc lectin complex in Entamoeba species using genomic data and sequence alignment techniques.
Limitations
The lower sequence coverage of E. dispar compared to E. histolytica could result in more errors in its sequence.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website