Performance of a new hand-held device for measuring exhaled nitric oxide
Author Information
Author(s): Alving K, Janson C, Nordvall L
Primary Institution: Karolinska Institutet
Hypothesis
The new hand-held device for measuring exhaled nitric oxide will perform comparably to the standard stationary device.
Conclusion
The hand-held device (NIOX MINO) and the stationary system (NIOX) are in clinically acceptable agreement, allowing for successful use in both adults and children.
Supporting Evidence
- The hand-held device showed a high success rate of ≥ 84% for both adults and children.
- The median of the intrasubject difference in exhaled NO for the two devices was -1.2 ppb, indicating slight higher readings from the hand-held device.
- The study included both healthy controls and atopic patients with and without asthma.
Takeaway
Researchers tested a new small device that measures a gas called nitric oxide in breath, and it worked just as well as a big machine used in hospitals.
Methodology
The study compared a new hand-held device with a standard stationary device by measuring exhaled nitric oxide in 71 subjects, including both healthy individuals and asthma patients.
Limitations
Some younger children had difficulty using the hand-held device, and a few subjects were excluded due to low nitric oxide levels.
Participant Demographics
Participants included 36 males and a mix of healthy controls and atopic patients aged 6 to 60 years.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% limits of agreement were -9.8 and 8.0 ppb.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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