Study of Genetic Variants INSIG2 and PFKP in Obesity
Author Information
Author(s): Andreasen Camilla H., Mogensen Mette S., Borch-Johnsen Knut, Sandbæk Annelli, Lauritzen Torsten, Sørensen Thorkild I. A., Hansen Lars, Almind Katrine, Jørgensen Torben, Pedersen Oluf, Hansen Torben
Primary Institution: Steno Diabetes Center, Copenhagen, Denmark
Hypothesis
Do the INSIG2 rs7566605 and PFKP rs6602024 variants contribute to obesity in the Danish population?
Conclusion
The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms do not play a significant role in the development of common forms of obesity in the Danish population.
Supporting Evidence
- No association with overweight or obesity was shown for the INSIG2 and PFKP variants.
- An interaction between INSIG2 and physical activity was observed.
- The study included a large sample size of 18,014 Danes.
Takeaway
The study looked at two genetic variants to see if they cause obesity, but found that they don't seem to have any effect.
Methodology
The study genotyped four genetic variants in a large sample of Danes and analyzed their association with obesity and related traits.
Potential Biases
Potential biases from self-reported physical activity levels.
Limitations
The study may not have captured all genetic and environmental interactions affecting obesity.
Participant Demographics
Participants were Danes, including normal weight, overweight, and obese individuals.
Statistical Information
P-Value
0.004
Confidence Interval
0.53 (SE 0.42)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website