eNOS Gene Polymorphism and Heart Disease
Author Information
Author(s): Çiftçi Ç, Melil S, Çebi Y, Ersöz M, Çağatay P, Kılıçgedik M, Duman B Süsleyici
Primary Institution: Istanbul Science University
Hypothesis
The study aims to evaluate the effects of the eNOS T-786C polymorphism on lipid parameters and the development of acute coronary syndrome (ACS) and coronary heart disease (CHD).
Conclusion
The high frequency of the eNOS -786C/C genotype in ACS patients suggests a genetic association with ACS.
Supporting Evidence
- The eNOS gene T-786C polymorphism frequencies were significantly different among ACS, CHD, and control groups.
- The CC genotype frequency was most prevalent in the ACS group compared to CHD and control groups.
- Left ventricule systolic dysfunction was highest in C/T genotype carriers among patients.
Takeaway
This study looked at how a specific gene variation might affect heart problems. They found that people with a certain gene type were more likely to have acute heart issues.
Methodology
The study analyzed genotype frequencies of the eNOS T-786C polymorphism in patients with ACS, CHD, and controls.
Limitations
The study had a relatively small sample size.
Participant Demographics
10 ACS patients (5 men, 5 women), 20 CHD patients (14 men, 6 women), and 31 controls (10 men, 21 women).
Statistical Information
P-Value
0.001
Statistical Significance
p = 0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website