Evolutionary origins of insulin resistance: a behavioral switch hypothesis
2007
Insulin Resistance as a Behavioral Switch Hypothesis
publication
Evidence: moderate
Author Information
Author(s): Milind G. Watve, Chittaranjan S. Yajnik
Primary Institution: Anujeeva Biosciences Pvt. Ltd.
Hypothesis
Is insulin resistance a socio-ecological adaptation that mediates transitions in reproductive strategy and lifestyle?
Conclusion
Insulin resistance may have evolved as a mechanism to adapt reproductive and life strategies rather than merely as a response to energy conservation.
Supporting Evidence
- Insulin resistance is linked to increased investment in offspring during gestation.
- Insulin resistance can reduce ovulation rates.
- Insulin signaling is associated with longevity and cognitive function.
Takeaway
Insulin resistance helps some people adapt to their environment by changing how they reproduce and live, like switching from having many babies to focusing on fewer babies with more care.
Limitations
The hypothesis has not been rigorously tested and relies on existing epidemiological patterns.
Digital Object Identifier (DOI)
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