Leishmanicidal Activity of Beauvericin
Author Information
Author(s): de Oliveira Filho Virlânio A., Gubiani Juliana R., Borgonovi Vitória D., Hilário Felipe, de Amorim Marcelo R., Minori Karen, Bertolini Vitor K. S., Ferreira Antonio G., Biz Andressa R., Soares Marcos A., Teles Helder L., Gadelha Fernanda R., Berlinck Roberto G. S., Miguel Danilo C.
Primary Institution: Instituto de Biologia, Universidade Estadual de Campinas
Hypothesis
Can beauvericin effectively kill Leishmania parasites in vitro and in vivo?
Conclusion
Beauvericin shows promising leishmanicidal effects, reducing parasite load in both in vitro and in vivo models.
Supporting Evidence
- Beauvericin was isolated in large amounts from Aspergillus terreus.
- Leishmania parasites showed morphological abnormalities in a dose-dependent manner when exposed to beauvericin.
- Beauvericin reduced the infectivity index of Leishmania at very low concentrations.
- In vivo assays demonstrated a significant reduction in lesion parasite load in treated mice.
- Topical administration of beauvericin delayed the progression of leishmaniasis ulcers.
Takeaway
Beauvericin is a substance that can help fight a disease caused by tiny parasites, making them less harmful to people.
Methodology
The study involved bioassay-guided fractionation of beauvericin from Aspergillus terreus and tested its effects on Leishmania parasites in vitro and in vivo.
Potential Biases
Potential bias in the selection of strains and methods used for testing.
Limitations
The study primarily focused on specific strains of Leishmania and may not represent all forms of the disease.
Participant Demographics
BALB/c mice were used for in vivo assays.
Statistical Information
P-Value
0.0157
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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