Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles
2024

Brain Maps of Cognitive Function and Brain Structure

Sample size: 38379 publication Evidence: moderate

Author Information

Author(s): Moodie Joanna E., Buchanan Colin, Furtjes Anna, Conole Eleanor, Stolicyn Aleks, Corley Janie, Ferguson Karen, Hernandez Maria Valdes, Maniega Susana Munoz, Russ Tom C., Luciano Michelle, Whalley Heather, Bastin Mark E., Wardlaw Joanna, Deary Ian, Cox Simon

Primary Institution: Cold Spring Harbor Laboratory

Hypothesis

Which regions of the human brain are most strongly related to individual differences in cognitive functioning and what are the underlying neurobiological properties of those regions?

Conclusion

The study identifies specific brain regions related to cognitive function and their neurobiological characteristics, revealing significant spatial correlations.

Supporting Evidence

  • The study analyzed data from 38,379 participants.
  • Cognitive function was assessed through various morphometry measures.
  • The findings show good cross-cohort agreement in brain-cognition associations.

Takeaway

This study looks at how different parts of the brain relate to how smart people are and what makes those parts of the brain work.

Methodology

Meta-analysis of vertex-wise g-cortical morphometry associations using data from three cohorts.

Participant Demographics

Participants aged 44 to 84 years from three cohorts.

Digital Object Identifier (DOI)

10.1101/2024.12.17.628670

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