Transporters in Candida albicans
Author Information
Author(s): Gaur Manisha, Puri Nidhi, Manoharlal Raman, Rai Versha, Mukhopadhayay Gauranga, Choudhury Devapriya, Prasad Rajendra
Primary Institution: Jawaharlal Nehru University, New Delhi, India
Hypothesis
What is the complete transportome of MFS proteins in the human pathogenic yeast Candida albicans?
Conclusion
The study identified 95 potential MFS transporters in Candida albicans, with most showing expression, which may play a role in antifungal resistance and nutrient transport.
Supporting Evidence
- 95 potential MFS proteins were identified in the C. albicans genome.
- 87 of the putative MFS genes were found to express at mRNA or protein levels.
- The study validated family designations of MFS proteins using the TC system.
Takeaway
Researchers found many proteins in Candida albicans that help it move important substances in and out of its cells, which could help it resist drugs.
Methodology
The study used computational analysis and RT-PCR to identify and validate the expression of MFS transporter genes in the Candida albicans genome.
Limitations
The expression of 8 putative MFS genes was not detected, suggesting they may be pseudogenes or expressed under specific conditions.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website