Genetic Variations in IGF Genes and Breast Cancer Risk
Author Information
Author(s): Patel Alpa V., Cheng Iona, Canzian Federico, Le Marchand Loïc, Thun Michael J., Berg Christine D., Buring Julie, Calle Eugenia E., Chanock Stephen, Clavel-Chapelon Francoise, Cox David G., Dorronsoro Miren, Dossus Laure, Haiman Christopher A., Hankinson Susan E., Henderson Brian E., Hoover Robert, Hunter David J., Kaaks Rudolf, Kolonel Laurence N., Kraft Peter, Linseisen Jakob, Lund Eiliv, Manjer Jonas, McCarty Catherine, Peeters Petra H. M., Pike Malcolm C., Pollak Michael, Riboli Elio, Stram Daniel O., Tjonneland Anne, Travis Ruth C., Trichopoulos Dimitrios, Tumino Rosario, Yeager Meredith, Ziegler Regina G., Feigelson Heather Spencer
Primary Institution: Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
Hypothesis
Do genetic variations in the IGF1, IGFBP1, and IGFBP3 genes influence circulating IGF levels and breast cancer risk?
Conclusion
The study found that while certain genetic variants in IGF1 and IGFBP3 are associated with circulating IGF levels, they do not significantly influence breast cancer risk.
Supporting Evidence
- Specific IGF1 SNPs accounted for up to 5% change in circulating IGF-I levels.
- Individual IGFBP3 SNPs were associated with up to 12% change in circulating IGFBP-3 levels.
- No associations were observed between these polymorphisms and breast cancer risk.
Takeaway
This study looked at how genes related to a growth factor might affect breast cancer risk, but it found that they don't really change the chances of getting breast cancer.
Methodology
The study analyzed genetic variations in IGF1, IGFBP1, and IGFBP3 among 6,912 breast cancer cases and 8,891 matched controls, focusing on their association with circulating IGF-I and IGFBP-3 levels.
Limitations
The study primarily included Caucasian women, which may limit the generalizability of the findings to other populations.
Participant Demographics
Primarily Caucasian women, with a majority being postmenopausal.
Digital Object Identifier (DOI)
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