How Epstein-Barr Virus Infects Epithelial Cells
Author Information
Author(s): Shannon-Lowe, Claire Rowe, Martin Sugden
Primary Institution: Cancer Research UK Birmingham Cancer Centre, School of Cancer Sciences, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom
Hypothesis
Transfer infection offers a mechanism for how EBV can infect epithelial cells during persistent infection.
Conclusion
The study reveals that memory B cells are the primary vehicles for transferring Epstein-Barr virus to epithelial cells, particularly at the basolateral surface.
Supporting Evidence
- EBV binds to CD21 on B cells, which activates adhesion molecules for interaction with epithelial cells.
- Transfer infection occurs primarily at the basolateral surface of polarized epithelial cells.
- Memory B cells are more efficient than naïve B cells in mediating transfer infection.
- Blocking antibodies to CD11b and LEEP-CAM significantly reduce transfer infection efficiency.
- Direct infection of epithelial cells is less efficient than transfer infection via B cells.
Takeaway
The Epstein-Barr virus can use memory B cells to infect epithelial cells, which is important for how the virus spreads in the body.
Methodology
The study used in vitro models of polarized epithelial cells to investigate the mechanisms of EBV transfer infection from B cells.
Limitations
The study primarily focuses on in vitro models, which may not fully replicate in vivo conditions.
Digital Object Identifier (DOI)
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