Chronic Kidney Disease and Uropathogen Resistance in Acute Pyelonephritis
Author Information
Author(s): Jung Yeon Soon, Shin Ho Sik, Rim Hark
Primary Institution: Kosin University College of Medicine
Hypothesis
Does chronic renal failure influence the spectrum and antimicrobial susceptibility of uropathogens in community-acquired acute pyelonephritis?
Conclusion
Chronic renal failure does not affect the isolation rates of different uropathogens or their susceptibility patterns to antimicrobials in patients with community-acquired acute pyelonephritis.
Supporting Evidence
- E. coli was the most common pathogen found in 58.3% of cases.
- Patients with chronic renal failure showed higher resistance rates to ampicillin and gentamycin.
- No significant differences in antibiotic sensitivity were observed between CRF and non-CRF patients.
Takeaway
This study looked at patients with kidney problems and found that their infections were not different from those without kidney problems when it came to the germs causing the infections or how well the germs responded to antibiotics.
Methodology
A retrospective analysis of medical records of 502 adults treated for community-acquired acute pyelonephritis over a ten-year period.
Limitations
The study was conducted at a single hospital and included only patients admitted there, and the CRF group was older than the non-CRF group.
Participant Demographics
502 adults (54 men, 448 women; mean age 61.7 years, range 18-98 years).
Statistical Information
P-Value
0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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