FEV1 Changes and Patient-Reported Outcomes in COPD
Author Information
Author(s): Marie Westwood, Jean Bourbeau, Paul W. Jones, Annamaria Cerulli, Gorana Capkun-Niggli, Gill Worthy
Primary Institution: Kleijnen Systematic Reviews Ltd., York, UK
Hypothesis
This systematic review investigates the relationship between changes in FEV1 and changes in health status with bronchodilator therapy in COPD patients.
Conclusion
Improvement in mean trough FEV1 is associated with proportional improvements in health status.
Supporting Evidence
- Thirty-six studies were included in the review, with 22 studies providing SGRQ data.
- Change in trough FEV1 and change in SGRQ total score were negatively correlated (r = -0.46).
- A 100 mL increase in FEV1 was associated with a statistically significant reduction in SGRQ of 2.5.
Takeaway
If patients' lung function improves, they often feel better too. This study looked at how these two things are connected.
Methodology
A systematic review of RCTs was conducted, analyzing data from six databases to assess the relationship between FEV1 changes and health status as measured by the SGRQ.
Potential Biases
The analysis combined treatment arms from different studies, which may affect estimates of correlation.
Limitations
The review was limited by the quality and size of the available data set, and many studies did not report numerical data.
Participant Demographics
The average age of participants was 64 years, with 72% male.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI 1.9, 3.1
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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