Large head metal-on-metal cementless total hip arthroplasty versus 28mm metal-on-polyethylene cementless total hip arthroplasty: design of a randomized controlled trial
2008

Comparing Two Types of Hip Replacement Surgery

Sample size: 100 publication Evidence: moderate

Author Information

Author(s): Wierd P. Zijlstra, Nanne Bos, Jos J. A. M. van Raaij

Primary Institution: Martini Hospital

Hypothesis

Large head metal-on-metal arthroplasties show less bone density loss and higher serum metal ion concentrations compared to 28 mm metal-on-polyethylene arthroplasties.

Conclusion

This study is designed to test whether large head metal-on-metal cementless total hip arthroplasty leads to less bone density loss and higher serum metal ion concentrations compared to 28 mm metal-on-polyethylene cementless total hip arthroplasty.

Supporting Evidence

  • Metal-on-metal hip replacements may reduce wear and improve longevity.
  • The study aims to provide randomized controlled evidence for the effectiveness of large head metal-on-metal arthroplasties.

Takeaway

This study is looking at two types of hip surgeries to see which one is better for keeping bones strong and reducing metal in the blood.

Methodology

A randomized controlled trial comparing two types of cementless total hip arthroplasties with assessments at multiple time points.

Potential Biases

The study is funded by Biomet Netherlands, which may introduce bias in the results.

Limitations

The study may have a drop-out rate and potential conversion to cemented cups if adequate cementless fixation fails.

Participant Demographics

Patients aged 18 to 80 with non-inflammatory degenerative joint disease of the hip.

Statistical Information

P-Value

< 0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1471-2474-9-136

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