Probiotic Lactobacillus rhamnosus and Vaginal Health
Author Information
Author(s): Sophie Coudeyras, Gwendoline Jugie, Marion Vermerie, Christiane Forestier
Primary Institution: University Clermont 1
Hypothesis
Can Lactobacillus rhamnosus adhere to cervical and vaginal cells and inhibit vaginosis-associated pathogens?
Conclusion
Lactobacillus rhamnosus Lcr35 can adhere to cervicovaginal cells and inhibit the growth of certain pathogens, making it a promising therapeutic candidate.
Supporting Evidence
- Lcr35 adhered rapidly to cervical and vaginal cells.
- Coculture assays showed a decrease in pathogen cell division after 4 hours.
- Lcr35 demonstrated bactericidal activity against Prevotella bivia and Gardnerella vaginalis.
Takeaway
This study shows that a type of good bacteria can stick to the cells in the vagina and help fight off bad germs that cause infections.
Methodology
In vitro adhesion assays and coculture experiments were performed using immortalized epithelial cell lines and vaginosis-associated pathogens.
Limitations
In vitro studies may not fully replicate in vivo conditions.
Statistical Information
P-Value
0.050
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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