The Role of Maternal Antibodies in Neuromental Disorders
Author Information
Author(s): A. J. Nahmias, Susanne Beckman Nahmias, Dan Danielsson
Primary Institution: Emory University
Hypothesis
Maternal transplacentally-acquired antibodies to infectious agents with molecular mimicry to the developing nervous system can cause neuromental disorders years later.
Conclusion
Preliminary results suggest that high levels of maternal antibodies to certain infectious agents may be linked to the development of schizophrenia in offspring.
Supporting Evidence
- Maternal antibodies to herpes simplex virus type 2 were found at higher levels in mothers of children who developed schizophrenia.
- Influenza virus antibodies were also higher in mothers of children with schizophrenia compared to controls.
- Maternal IgG antibodies to toxoplasma were significantly more prevalent in cases than controls.
Takeaway
Moms can pass antibodies to their babies that might later cause mental health issues, like schizophrenia, when the kids grow up.
Methodology
The study involved analyzing maternal and newborn sera from a large cohort of pregnant women and their offspring, with follow-up for neuromental disorders.
Potential Biases
Potential biases may arise from the retrospective nature of the data and the reliance on existing serum samples.
Limitations
The study relies on historical data and may not account for all confounding factors influencing neuromental disorders.
Participant Demographics
The study included a diverse population of pregnant women from various regions in the US.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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