Managing Acute Thromboembolic Disease with Heparin-Induced Thrombocytopenia
Author Information
Author(s): Serasli Eva, Antoniadou Maria, Tsara Venetia, Kalpakidis Vassilis, Megalopoulos Angelos, Trellopoulos George, Papaioannou Georgia, Christaki Pandora
Primary Institution: General Hospital G. Papanikolaou, Thessaloniki, Greece
Hypothesis
Can fondaparinux and inferior vena cava filters effectively manage patients with HIT and massive pulmonary embolism?
Conclusion
Fondaparinux combined with inferior vena cava filters can successfully manage patients with HIT and massive pulmonary embolism.
Supporting Evidence
- The first patient had a history of thrombocytopenia after low molecular weight heparin.
- The second patient had thrombophilia due to hyperhomocystinaemia.
- Both patients were successfully treated with fondaparinux and IVC filters.
Takeaway
This study shows that a special medicine called fondaparinux, along with a filter in the body, can help people who have serious blood clots and a problem caused by a medicine called heparin.
Methodology
Two case reports of patients with HIT and massive pulmonary embolism treated with fondaparinux and inferior vena cava filters.
Limitations
The expression of ELISA results may not correlate with the relative risk of thrombosis.
Participant Demographics
Two patients: a 60-year-old woman and a 32-year-old man.
Digital Object Identifier (DOI)
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