Seabuckthorn Leaf Extract Reduces Lung Leakage in Hypoxia
Author Information
Author(s): Purushothaman Jayamurthy, Suryakumar Geetha, Shukla Dhananjay, Jayamurthy Himani, Kasiganesan Harinath, Kumar Rajesh, Sawhney Ramesh Chand
Primary Institution: Defence Institute of Physiology and Allied Sciences, DRDO, Ministry of Defence, India
Hypothesis
Can seabuckthorn leaf extract reduce hypoxia-induced pulmonary vascular leakage in rats?
Conclusion
Seabuckthorn leaf extract significantly protects against hypoxia-induced pulmonary vascular leakage by reducing inflammation and oxidative stress.
Supporting Evidence
- Seabuckthorn leaf extract reduced lung water content in hypoxic rats.
- The extract decreased the leakage of fluorescein dye into the lungs.
- It also lowered levels of proinflammatory cytokines in the bronchoalveolar lavage fluid.
- The extract improved antioxidant enzyme levels in the lungs.
- VEGF levels in the plasma and BALF were significantly reduced with treatment.
Takeaway
This study found that seabuckthorn leaves can help protect lungs from damage when animals are exposed to low oxygen levels.
Methodology
Rats were exposed to hypoxia and treated with seabuckthorn leaf extract to measure lung water content and vascular leakage.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Male Sprague-Dawley albino rats weighing 170–200 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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